The Science Behind Our Ingredients: Why Your Dog Deserves the Best

What you feed your dog matters. That’s why we did the research—so you don’t have to. Every ingredient in Complete Canine’s all-in-one supplement is backed by published research and trusted veterinary insights. Below, we break down the key ingredients in our formula and the science that supports them. Have questions? Reach out using the contact form below.

Joint & Mobility Support

Glucosamine and Chondroitin Sulfate

These two ingredients are commonly used to support joint health in dogs, especially those suffering from osteoarthritis. A 2017 review published in the Open Veterinary Journal discusses the benefits and limitations of glucosamine and chondroitin supplementation. While more clinical trials are needed, they remain among the most researched joint-supportive compounds in canine health.

Bhathal A, Spryszak M, Louizos C, Frankel G. "Glucosamine and chondroitin use in canines for osteoarthritis: A review." Open Vet J. 2017;7(1):36-49.

Methylsulfonylmethane (MSM)

MSM is a powerful anti-inflammatory compound that helps relieve pain and stiffness in dogs with arthritis. A 2012 study in the Journal of Animal Physiology and Animal Nutrition found that MSM, in combination with other ingredients, improved mobility and reduced pain in arthritic dogs.

Gupta RC et al. "Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs." J Anim Physiol Anim Nutr. 2012;96(5):770-7.

Gut & Digestive Health

Probiotics (Lactobacillus & Bifidobacterium)

Probiotics play a crucial role in maintaining gut health, supporting digestion, and enhancing immune function. A 2015 study in the Journal of Applied Microbiology highlighted their benefits in canine and feline wellness, especially in alleviating intestinal diseases.

Grześkowiak Ł et al. "Microbiota and probiotics in canine and feline welfare." Anaerobe. 2015;34:14-23.

Skin, Coat & Immune Support

Zinc (Chelated Form)

Zinc is vital for skin integrity, immune health, and coat quality. A study published in Veterinary Dermatology found that chelated zinc offers superior absorption and effectiveness compared to inorganic forms, especially when paired with linoleic acid.

Marsh KA et al. "Effects of zinc and linoleic acid supplementation on the skin and coat quality of dogs." Vet Dermatol. 2000;11:277–284.

Curcumin (Turmeric Extract with Piperine)

Curcumin is known for its anti-inflammatory and antioxidant effects. While much of the research has been conducted on humans, the findings have promising implications for dogs. A review in the journal Foods outlines its potential benefits for reducing inflammation and oxidative stress.

Hewlings SJ, Kalman DS. "Curcumin: A Review of Its Effects on Human Health." Foods. 2017;6(10):92.

Heart, Brain & Longevity Support

Coenzyme Q10 (Ubiquinol Form)

CoQ10 supports cardiovascular function and cellular energy. A 2021 review in Nutrients highlighted its use in managing heart conditions and its broader applications for longevity and wellness.

Testai L et al. "Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases." Nutrients. 2021;13(5):1697.

Omega-3 Fatty Acids (DHA & EPA from Fish Oil)

Omega-3s are essential for reducing inflammation and supporting joint, brain, and heart health. A 2010 study in the Journal of the American Veterinary Medical Association found that dogs with osteoarthritis showed improved weight-bearing and reduced discomfort after fish oil supplementation.

Roush JK et al. "Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis." J Am Vet Med Assoc. 2010;236(1):67-73.

Conclusion

At Complete Canine, we’re committed to transparency and trust. Every ingredient in our liquid supplement is carefully selected based on real science—not trends. We're proud to offer a solution that supports your dog's health in a comprehensive, natural way.

Still curious? Explore our full reference page here or contact us with any questions.